National use of proton pump inhibitors from 2007 to 2011.

National Use of Proton Pump Inhibitors From2007 to 2011 Proton pump inhibitors (PPIs) are a class of therapeutically equivalent medications when used at equivalent doses.1,2 Despite this, high-cost PPIs continue to be used when lowcost equivalents are available. We sought to estimate the national loss associated with the use of high-cost PPIs over their lower-cost alternatives. Furthermore, we investigated the sociodemographic factors associated with the use of high-cost PPIs.